Haploidentical hematopoietic SCT for acquired severe aplastic anemia using post-transplant high-dose CY
نویسندگان
چکیده
منابع مشابه
Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant
BACKGROUND Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy (IST). The current study evaluated the feasibility of upfront haploidentical HSCT in SAA patients. METHODS We conducted a multicenter study b...
متن کاملHaploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT...
متن کاملClinical applications of haploidentical hematopoietic stem cell transplantation in severe aplastic anemia.
OBJECTIVE The purpose of this study was to investigate the efficacy and safety of haploidentical allogeneic hemopoietic stem cell transplantation (allo-HSCT) in severe aplastic anemia (SAA) and prophylaxis of complications involved. PATIENTS AND METHODS 8 patients with clinically diagnosed SAA (5 cases of SAA-I and 3 cases of SAA-II) were recruited, with the parents as the donors of hemopoiet...
متن کاملThe treatment of severe acquired aplastic anemia.
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متن کاملAcquired severe aplastic anemia: progress and perplexity.
T HE PATHOPHYSIOLOGY and treatment of acquired severe aplastic anemia (ASAA) has been the subject of recent reviews.’2 Whether idiopathic or idiosyncratic, ASAA is a “likely-to-be-fatal” disease.3 However, it has long been recognized that some patients will recover spontaneously, and a few lucky ones may do so with surprisingly rapid restoration of hematopoiesis.35 The inherent unpredictability...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2014
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2014.222